منابع مشابه
Is hypertension an autoimmune disease?
T cells are required for significant blood pressure elevation in mouse models of hypertension. Recent evidence suggests that the treatments that raise blood pressure in these animal models also cause oxidation within DCs, resulting in formation of isoketal adducts of self-proteins, which activate antigen-presenting functions of these cells and serve as a source of modified self-antigens. T cell...
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psoriasis is a chronic, inflammatory and proliferative skin disease that has a wide distribution throughout the world. the immune system plays a critical role in developing this disease. in this survey, we have studied 50 patients suffering from psoriasis and 50 control subjects for various immunological factors, simultaneously. anti-stratum corneum (sc) antibody was evaluated by immunofluoresc...
متن کاملPulmonary arterial hypertension: an autoimmune disease?
P ulmonary arterial hypertension (PAH) is a rare condition that occurs as a consequence of chronic obstruction of small pulmonary arteries due to endothelial cell, vascular smooth muscle cell and fibroblast dysfunction and proliferation [1]. In recent years, major advances have been achieved in the understanding of PAH pathophysiology [1–7]. It has been firmly demonstrated that pulmonary artery...
متن کاملIs atherosclerosis an autoimmune disease?
Immunologic research into pathogenic mechanisms operating in autoimmune-mediated atherosclerosis initially focused on adaptive immunity. Current interest is directed to more basic inflammatory mechanisms. Chronic inflammation (innate immunity-associated) may trigger initial events that can lead to atherosclerotic cardiovascular disease. This chronic inflammation may start early in life and be p...
متن کاملIs autism an autoimmune disease?
Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impaired social interaction and communication, often accompanied by repetitive and stereotyped behavior. The condition manifests within the first 3 years of life and persists into adulthood. There are numerous hypotheses regarding the etiology and pathology of ASD, including a suggested role for immune dysfunc...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci77766